Eastern Panama Vacations from $821

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Punta Chame Club and Resort
Central Hotel Panama Casco Viejo
Villa Marina Hotel
Casa Lefevre By Wynwood House
Megapolis Hotel Panamá
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Discover the most popular places to visit in Eastern Panama

Eastern Panama Hotel Deals

Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale Cacique Provincia de Colón
Fully refundableReserve now, pay when you stay
$207 nightly
The price is $228 total per night from Jun 2 to Jun 3
$228 total
Jun 2 - Jun 3
Total with taxes and fees
10/10 Exceptional! (10 reviews)
"The views from this mountain-top boutique hotel are extraordinary."

Reviewed on Feb 1, 2026

Ciel y Miel
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
$126 nightly
The price is $139 total per night from May 31 to Jun 1
$139 total
May 31 - Jun 1
Total with taxes and fees
9.8/10 Exceptional! (17 reviews)
"Amazing location, beautiful vistas of mountains, forest and ocean. Very relaxing environment with infinity pool. Well maintained grounds. Wonderful breakfast and dinners. Jose and Anna were amazing hosts. Marijka and Garth"

Reviewed on Feb 19, 2026

Ranchos de Chalia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.