Eastern Panama Vacations from $603

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B
Hotel Posada Los Delfines
Round the point Bungalow
The Sands by Wynwood House
The Gray by Wynwood House
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Discover the most popular places to visit in Eastern Panama

Eastern Panama Hotel Deals

Private Over the Water Cabin on San Blas Island
Private Over the Water Cabin on San Blas Island
2 out of 5
9.542876, -78.899058, Narganá, San Blas
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on Feb 16, 2022

Private Over the Water Cabin on San Blas Island
Ranchos de Chalia
Ranchos de Chalia
3 out of 5
Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón
$140 nightly
The price is $153 total per night from Jul 2 to Jul 3
$153 total
Jul 2 - Jul 3
Total includes taxes and fees
9.6/10 Exceptional! (4 reviews)
"Such a beautiful place! Lovely view and very close to access to the beach. 5 min small boats ride. Relaxing environment mixing mountain feeling and beach view. Very cozy for family of 2 kids. The people in charge there are exceptional!"

Reviewed on Apr 19, 2025

Ranchos de Chalia
 San Blas Paradise Private Cabins on Shipwreck Island - meals included
San Blas Paradise Private Cabins on Shipwreck Island - meals included
2 out of 5
Perro Island, Narganá, Guna Yala
$169 nightly
The price is $186 total per night from Jul 1 to Jul 2
$186 total
Jul 1 - Jul 2
Total includes taxes and fees
San Blas Paradise Private Cabins on Shipwreck Island - meals included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Eastern Panama Vacation Packages

Eastern Panama Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Tocumen Intl. Airport (PTY)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.