Eastern Panama Vacations from $723

Name: Ciel y Miel
Price range: $513 total
Rating: 10

Book a Hotel + Flight or Car together to unlock savings

Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

The Latest Eastern Panama vacation packages

Price found within the past 48 hours. Click for updated prices.

Central Hotel Panama Casco Viejo

Casco Viejo

$723

per person

Nov 20 - Nov 23

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

9/10 Wonderful! (997 reviews)

The service was excellent, the staff very friendly and attentive at all times. The food was varied. The hotel was very clean. Highly recommended!!!

Reviewed on Oct 5, 2025

Central Hotel Bocas del Toro

Save 100% on your flight

$1,706

per person

Dec 28 - Jan 2

found 1 day ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

No reviews

Kooteja Anton Valley ËRA

Save 100% on your flight

$745

per person

Jan 1 - Jan 8

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

6/10 (2 reviews)

La Coralina Island House

$1,359

per person

Dec 18 - Dec 23

found 12 hours ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

9.4/10 Exceptional! (86 reviews)

Everything was great , lovely and peaceful place.

Reviewed on Sep 29, 2025

Isla Palenque Member of the Cayuga Collection

Save 100% on your flight

$2,263

per person

Nov 22 - Nov 25

found 1 day ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

10/10 Exceptional! (6 reviews)

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Discover the most popular places to visit in Eastern Panama

Museum of the Kuna Nation

You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Masargantupo. Stroll along the seaside or experience the area's festivals.

Porvenir Museum

You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.

Eastern Panama Hotel Deals

San Blas Paradise Private Cabins on Shipwreck Island - meals included

Perro Island, Narganá, Guna Yala

$169 nightly

$186 total

Oct 12 - Oct 13

Total with taxes and fees

Private Ocean-Front Cabin with private bathroom on San Blas Island

Diablo Island, Narganá, Guna Yala

$188 nightly

$207 total

Oct 12 - Oct 13

Total with taxes and fees

Ciel y Miel

Caillle Principale, Cacique, Provincia de Colón

$466 nightly

$513 total

Oct 12 - Oct 13

Total with taxes and fees

10/10 Exceptional! (9 reviews)

"All was good"

Reviewed on Jul 14, 2025

See all 176 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.