
Eastern Panama Vacations from $821
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Your Eastern Panama Vacation
Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.
The Latest Eastern Panama vacation packages

Punta Chame Club and Resort
Reviewed on Jan 2, 2020

Central Hotel Panama Casco Viejo
Reviewed on May 29, 2026


Casa Lefevre By Wynwood House
Reviewed on May 19, 2026

Megapolis Hotel Panamá
Reviewed on May 26, 2026
Discover the most popular places to visit in Eastern Panama
Porvenir Museum
You can spend time browsing the exhibits at Porvenir Museum during your travels in Narganá. Amble around the area's seaside or experience its festivals.
Museum of the Kuna Nation
You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals.
Eastern Panama Hotel Deals

Ciel y Miel
"The views from this mountain-top boutique hotel are extraordinary."
Reviewed on Feb 1, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."
Reviewed on Mar 15, 2026

Ranchos de Chalia
"Amazing location, beautiful vistas of mountains, forest and ocean. Very relaxing environment with infinity pool. Well maintained grounds. Wonderful breakfast and dinners. Jose and Anna were amazing hosts. Marijka and Garth"
Reviewed on Feb 19, 2026
Find the Best Eastern Panama Vacation Packages
Eastern Panama Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Tocumen Intl. Airport (PTY) |


















